In mild of the most recent growth of a yearslong examine carried out by groups of docs in Türkiye’s main establishments following the footsteps of the chemistry analysis of Nobel laureate Professor Dr. Aziz Sancar, a brand new entrance has opened within the “fight against cancer.” The findings now reveal that the malicious illness might be prevented with using particular medicine that had been already examined on animals.
Sancar, a Turkish scientist working within the United States and co-winner of the 2015 Nobel Prize in chemistry, has labored for round 10 years to check DNA mechanisms. The scientist found final yr a particular molecule (EdU molecule) that might be used within the battle towards mind most cancers.
According to the brand new analysis – which is the primary on the earth – the one solution to “prevent cancer” is to delete the protein referred to as “CRY” from the mechanisms that regulate the organic clock within the absence of a gene referred to as p53, which is named the “guardian angel” towards most cancers.
The p53 prevents the uncontrolled proliferation of cells inflicting 50% of all cancers. Through Sancar’s analysis, it was discovered that if this gene is mutated, most cancers might be prevented as a result of when CRY is destroyed, different pathways that lead the most cancers cell to “self-death” are activated within the dwelling physique and the tumor is blocked earlier than it even happens.
However, the professor famous that isn’t potential to use this deletion (genetic intervention) to people, that’s, to destroy the CRY protein by genetic means as the method was solely examined on animals, particularly mice.
A gaggle of Turkish scientists from Koç University carried out a examine that may “medicate” this protein. Proving the effectiveness of the “drug candidate” molecule in animal experiments, the researchers are making ready for part research on people.
Professor Dr. Halil Kavakli, the pinnacle of the analysis which is carried out by a number of main establishments, famous that he labored facet by facet with Sancar for 5 years, saying that this new discovery, which remains to be within the analysis part, may take its place on the cabinets as a medication in pharmacies inside 5 to 6 years if “everything goes well.”
At the second the group has begun research on mice to see the efficacy of this molecule, particularly in pancreatic and liver cancers, which now have very excessive mortality charges.
From the analysis group, Associate Dr. Şeref Gül researched round 2 million pure molecules to search out the potential molecule that may destroy the CRY protein.
After the molecule that was regarded as efficient was found, a professor from Medipol University Pharmacology Department named Dr. Mustafa Güzel chemically synthesized this molecule obtained from sea creatures and therefore obtained the “medicine form” that may be given to experimental animals. Professor. Dr. Alper Okyar from the IU Faculty of Pharmacology carried out the side-effect research of the drug candidate molecule in animals and the assessments on the effectiveness of the drug.
Kavaklı famous that the examine, which really took round three years, proved to haven’t any uncomfortable side effects. He mentioned they used a mouse that didn’t carry the p53 gene. While the management group of mice that had been identified with tumoral gland most cancers died in about 20 weeks. He mentioned they noticed that mice with the drug lived 25% longer.
“After all, this exhibits that, while you delete CRY within the absence of the p53 gene, you’ll be able to actually defend the animal from most cancers formation. We have accomplished the laboratory and animal experiments, which we name preclinical. Now, once we have a look at our molecule, we’re prepared for part research. If every part goes effectively, we estimate that it’s going to take its place on the pharmacy cabinets as a drug in 5 to 6 years,” he concluded.
